Hey,
She will probably do both. It helps to send the picture but if you ask her for one she will probably send one back to you AND your magazine photo. but, just like the other user said, nobody has seen any successes of her so she might not respond. but, it's worth a try! maybe you will get lucky! You might want to google 'Ellen Pompedo Fan Mail Addresses' to see if any others pop up.
Good Luck! {up}
Kate :D

I have never seen a success from her

If I were to send Ellen a magazine picture to sign would she sign it and send it back to me or would she send her own signed picture to me? Would the Grey's Anatomy address work for her?

Thanks any help would be great