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The show is centered on five characters: roommates Leonard Hofstadter and Sheldon Cooper, two physicists employed at the California Institute of Technology (Caltech); Penny, How I Met Your Mother Season 8 Episode 6 a waitress and aspiring actress who lives across the hall; and Leonard and Walking Dead Season 3 Episode 5 Sheldon’s equally geeky and socially awkward friends Gossip Girl Season 6 Episode 5 and co-workers, aerospace engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. 90210 Season 5 Episode 5 The geekiness and intellect of the four guys is contrasted for comic effect with Penny’s social skills Sons of Anarchy Season 5 Episode 10 and common sense. Over time supporting characters have been promoted to starring roles: Leslie Winkle, a physicist colleague at Caltech and, New Girl Season 2 Episode 7 at different times, a lover of both Leonard and Howard.